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Several studies published between 2021 and 2024 for HCC have shown that the ALBI grade plays a role in aiding outcome evaluation and liver reserve evaluation at several stages in stereotactic body radiotherapy of the liver, and thus it is helpful in determining the prognosis of HCC patients who undergo this therapy (4446), and that the rate of hepatotoxicity occurs at an elevated rate as the grade increases

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During the blinded data review an indication of period effect was noted and properly registered as follow up action according to the Statistical Analysis Plan of the trial protocol