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Tet-1 can interact specifically with motor neurons and is capable of retrograde delivery to the neuronal cells [102]

Drug delivery of macromolecules can also be afforded via this transport route, which relies on the electrostatic interactions between the surface of positively charged NPs (functionalized for instance with positive polymers, cationic lipids, albumin) and negative charges naturally present on endothelial plasma membrane (due to the presence of anionic proteoglycans) of the BBB (Poon and Garipy, 2007

Erickson, A.M., et al., Identification of a variant antioxidant response element in the promoter of the human glutamate-cysteine ligase modifier subunit gene

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