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10.1126/sciadv.ade9585 14 AndrewsN

doi: 10.1053/jhep.2003.50331 25 ChenLYangHLiHHeCYangLLvG

3,5-diCQM drives melanogenesis in a dose-dependent manner, and the molecular mechanism underlying its ability to induce pigmentation is through activation of the p38 signaling pathway, phosphorylation and activation of CREB, and a cAMP/PKA dependent signaling pathway, which in turn upregulates the transcription factor MITF, thereby activating tyrosinase activity (Kim et al., 2015)