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Stem Cell Reports 2, 295310

We used 18-month-old mice for organoid isolation and NanoSeq sequencing of wild-type and Polk-/- mice, and 7-month-old mice for cholangiocyte organoid isolation of Xpa-/-Polk-/-, Xpc-/-Polk-/- and age-matched controls

However, the regulatory role of mitochondrial dynamics in aging has not yet been clearly explained

Furthermore, SBT system-derived ICC was identified by the expressions of HA, Myc, CK19 (a biomarker of BECs and ICC), and Ki67 (a biomarker for proliferation) (Fig