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Rats treated with TMAO have been shown to increase inflammatory markers and promote early atherosclerosis modifying lipid metabolism and biomarkers

Clin Ther 1995;17:176-85

Taken together with the findings that utilization of esketamine as an antidepressant increases LAC levels [59], the fact that the decrease in LAC levels in subjects with MDD is independent of psychotropic drug treatment raises the possibility that increasing LAC levels may be needed to induce antidepressant effects