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Plant Physiol Bioch 158:4352 Rutowicz K, Puzio M, Halibart-Puzio J, Lirski M, Kotlinski M, Kroten MA, Knizewski L, Lange B, Muszewska A, Sniegowska-Swierk K, Koscielniak J, Iwanicka-Nowicka R, Buza K, Janowiak F, Zmuda K, Joesaar I, Laskowska-Kaszub K, Fogtman A, Kollist H, Zielenkiewicz P, Tiuryn J, Siedlecki P, Swiezewski S, Ginalski K, Koblowska M, Archacki R, Wilczynski B, Rapacz M, Jerzmanowski A (2015) A Specialized Histone H1 variant is required for adaptive responses to complex abiotic stress and related DNA methylation in Arabidopsis

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40 Future directions There is a significant paucity of drugs to prevent ACV associated nephrotoxicity, but NAC showed a promising protective effect against ACV-induced nephrotoxicity in this study

miRNAs dysregulation In PAH, miRNA dysregulation occurs in lung tissues and in cultured PAECs, PASMCs, and fibroblasts [10]