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Acknowledgments The authors would like to thank Doug Fox, Michael Ingling, Joseph Kalish, Maurice Linder-Jackson, Sarah Marcum, Laura Milovic, Arwa Muhamed, and Ashley Thayaparan for their technical assistance in the working memory task

To further support the efficacy of system x c inhibitor on Tamoxifen tumors, IKE, a specific system x c inhibitor with excellent metabolic stability was used in the ZR-75-1-TamR xenografts (Fig