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Because exogenous -KG minimally contributes to the TCA cycle because of the lack of a mitochondrial importer 27 , this result suggests that exogenous -KG functions outside of the mitochondrion in shGDH1 cells under this context

Virrey JJ, Dong D, Stiles C, Patterson JB, Pen L, et al

As the terminal stage of various CVDs, HF is associated with a persistently high rate of morbidity, hospital readmission, and mortality in patients and has become a major public health problem worldwide, with more than 60 million cases diagnosed globally (90)

Because biochemical studies had failed to reveal unequivocal functions for TNC and TNR, our laboratory undertook a genetic approach to identify disease caused by TNX in humans