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Some superoxides are transported to the cytosol, where they are dismutated to H 2 O 2 by the cytosolic enzyme SOD1 [16]

Here the SERMs tamoxifen, raloxifene and genistein have been shown to promote skin healing [183, 184]

Future research could further explore the role of potential pathways such as NF-B or MAPK, and evaluate the potential toxic side effects of pedunculagin on the liver and kidneys