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5 This demonstrates how the GLU NMDA receptor and its 7 subunits are intimately associated with various psychotic symptoms when genetic or non-genetic factors (antagonists or antibodies) drastically reduce its activity

Conversely, senescence can also affect insulin signaling and glucose and lipid metabolism by reducing the expression or activity of insulin receptors or their substrates, increasing the levels of inflammatory cytokines or oxidative stress markers, impairing mitochondrial function or autophagy, or altering the composition or function of gut microbiota