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Also, oral administration increases the risk of systemic side effects

For each iteration, we regenerated a new model based on the gene expression and a partial set of the metabolite uptake and secretion rates and used these models to predict the flux rate through the reaction whose flux measurement was omitted

Deficiencies in zinc have been observed in some women with PCOS, and it has been hypothesized that this may contribute to the insulin-resistant phenotype of the condition