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At physiological concentrations, lactate acts as an important metabolic signaling molecule, promoting wound healing by regulating cellular signaling, stimulating neovascularization, and enhancing fibroplasia, among other mechanisms (Zhang et al., 2019

16 Another recent retrospective study found that if those with pre-existing avascular necrosis and subchondral insufficiency fracture are excluded from analysis, patients treated with hip CSI did not have significantly higher rates of short-term hip OA progression or femoral head articular surface collapse

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