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Methylfolate from food varies significantly based on cooking methods (folate is heat-sensitive)

Kharat M, Skrzynski M, Decker E, McClements D (2020) Enhancement of chemical stability of curcumin-enriched oil-in-water emulsions: impact of antioxidant type and concentration

These antibodies are seen in patients with autoimmune disorders with demyelination, and also in POTS/dysautonomia, implying the need for immune support, with treatment like IVIG (IV immunoglobulin therapy)

That said, a smaller ratio pertaining to infertility aetiologies are contributed by these specific disorders and failed to explain many of the multifactorial causes (Reference Joshi and Chan41)