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Emerging biomarkers, including miR-125b-2-3p and sulfatase 1 (SULF1), show promise in predicting VC severity, highlighting opportunities for early intervention ( Figure 1 delineates the dysregulated mineral metabolism axis in CKD, wherein FGF-23 induces parathyroid hyperplasia and downregulates calcium-sensing receptors (CaSR), abrogating calcium-mediated suppression of PTH secretion ( FIGURE 1 3 CKD-associated immune dysregulation 3.1 Chronic inflammation and oxidative stress Chronic kidney disease is marked by a persistent state of low-grade inflammation, a critical factor driving disease progression and its associated complications, such as cardiovascular disease (CVD) (31)

The reported affected individuals have neonatal cholestasis with severe pruritus and hepatosplenomegaly

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Tan TMM, Minnion J, Khoo B, Ball LJ, Malviya R, Day E, et al