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Through a non-enzymatic reaction, SLG specifically induces D-lactylation at the K310 site of the NF-B subunit RelA, thereby inhibiting NF-B activation and reducing the secretion of pro-inflammatory cytokines (66)

Sickness behavior is a physiological behavioral response principally induced and regulated by proinflammatory cytokines, including interleukin 1 (IL-1), IL-6 and tumor necrosis factor (TNF), which act centrally to induce sickness behaviors, including pyrexia

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The preparation should be applied externally to the skin, massaged or introduced using physical methods that support the transport of active substances through the epidermis