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Notably, in this loop, pyroptosis is primarily responsible for the rapid amplification of acute inflammation, whereas ferroptosis drives disease progression toward an irreversible direction through sustained depletion of structural cells

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Representative human CXorf21 cDNA and human CXorf21 protein sequences are well known in the art and are publicly available from the National Center for Biotechnology Information (NCBI) (see, e.g., NCBI