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Some animal studies have shown a decrease in uric acid levels in animals receiving chanca piedra supplements ( Liver disease Due to its antioxidant content, chanca piedra may improve liver function and help protect the liver from cellular damage caused by free radicals unstable compounds that can cause damage when they build up in your body in high levels ( The herb also appears to be helpful for treating hepatitis B, an inflammatory viral infection of the liver at least in animal and test-tube studies ( Because some other herbs in the Phyllanthus genus exhibit strong antiviral activity against hepatitis B potentially rivaling that of the antiviral medication interferon researchers theorize that chanca piedra may have similar effects ( Still, most of this research has been done in animal or test-tube studies

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Additionally, clinical studies are also required to understand whether there is correlation of serum or synovial fluid butyrate levels with ferroptosis markers (e.g., GPX4, ROS) or disease severity in OA patients, and the chondroprotective efficacy of butyrate supply to beneficial bacteria by probiotics or dietary fibers