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First, much of the mechanistic evidence derives from animal or cell-based studies, whereas human data are comparatively scarce and often limited to small cohorts or end-stage HF biopsies (Lopaschuk et al., 2010)

Caffeine consumed at very high levels 6-9 mg/caffeine/kg/BW can lead to negative health and performance effects: Gastrointestinal issues Nausea or shaking Headaches Anxiety & nervousness Heart palpations What is a healthy or acceptable/safe amount of caffeine

Glutathione plays a pivotal role in neutralising reactive oxygen species such as free radicals and peroxides, thus protecting the cells from oxidative stress