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M2-polarized macrophages mediate wound healing through Akt, ERK1/2, and STAT3 pathway 197,198,199,200 , and the promoting effect of lactate on the polarization and function of M2 macrophages has been discussed

Two notable proteins produced by SARS-CoV-2 are the spike, which is expressed on the virus envelope for attachment to receptors on host cells, and the RNA-dependent RNA polymerase (RdRp), which is required for replication of the virus ~30,000 nucleotide RNA genome [1]

The plasma antioxidant capacity increased dose-dependently with the elevation of serum and cerebrospinal fluid UA concentrations and was associated with favorable clinical outcomes [105]

Rare mutations related to decreased immune responses, known as inborn errors of immunity, are associated with an elevated risk of severe mononucleosis