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Results White blood cells count (WBC) in old and young rats Animals which WBC count was outside the norm (above 8.0 or under 2.0 cells [ 10 9 /L]) were excluded from our experiments

The opposite effect of CK1 in erythroid precursors and mature RBCs might be explained by the lack of the caspase-10-Bid axis in erythrocytes, which is at least partly responsible for anti-apoptotic action of CK1 in the erythroid precursors

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Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired