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Functional characterization of the tetravalent human Fc fusion VNAR constructs The in vitro neutralizing potency and TNF- binding affinities of the monomeric VNAR D1 and C4 and a corresponding biparatopic tetravalent human Fc fusion proteins (referred to as ELN22-108) consisting of 2x D1 and 2x C4, have been previously reported (Fig

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