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CJC-1295 CJC-1295 is also generally well-tolerated, but its longer activity can occasionally cause mild water retention, joint stiffness, or increased appetite in some individuals

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However, this theory has largely fallen out of favor due to a number of discrepancies, such as the fact that the therapeutic effects of antidepressants take weeks to develop even though monoamine levels are elevated within hours of administration, and the fact that only about 40% of patients respond satisfactorily to treatment (Trivedi et al., 2006)

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