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Mechanistically, we found that CRAT downregulation promoted OC growth and metastasis by increasing mitochondrial biogenesis to facilitate mitochondrial metabolism through reducing the acetylation of peroxisome proliferator-activated receptor- coactivator (PGC-1)

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10.1016/j.fertnstert.2011.10.012 73

In 2012, the Stockwell team officially named the cancer cell death induced by Erastin and RSL3 as"ferroptosis,"characterized by its iron dependency and lipid peroxidation, contrasting sharply with apoptosis, autophagy, and necrosis [9]