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For example, a retrospective cohort study of prediabetic patients (Hemoglobin A1c 5.7%6.4%, no use of antidiabetic drugs, and no prior diagnosis of type 2 diabetes mellitus (T2DM)) indicated that prediabetes is associated with an increased risk of PD, with a hazard ratio of 1.07 (95% confidence interval: 1.001.14) [19]

A specific oxidoreductase, previously known as apoptosis-inducing-factor mitochondrial-2 (AIFM2), capable of recycling reduced ubiquinol (Co-enzymeQ 10 H 2 ) from ubiquinone at the expense of NAD(P)H, has been presented as a potential ferroptosis inhibitor due to the fact that its overexpression complements the loss of GPx4 in PFA1 and human fibrosarcoma (66, 67)

Most are naturally occurring, and their presence in food is likely to prevent oxidation or to serve as a natural defense against the local environment