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L-theanine works by increasing levels of neurotransmitters in the brain that promote relaxation and reduce stress, such as GABA, dopamine, and serotonin

24 More comprehensive studies conducted by the NIH-funded Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network found that 44% of IC/BPS patients had at least one additional COPC

While general guidelines suggest 50-200mg daily administered in single or split doses over 8-12 week cycles, optimal protocols emerge through careful self-monitoring and responsive adjustments