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If you've used large water volumes, light blue color may be normal

358 Abnormal expression of transport proteins/receptors in the BBB, such as downregulation of LRP1 which exports A from the brain to the blood, impaired function of Pgp, and upregulation of RAGE that facilitates the entry of A from the blood into the brain, could be potential reasons for impaired A clearance and substantial accumulation in the brain

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Oncotarget 7(23):3403834051 Qian M et al (2024) A biodegradable nanosuspension locally used for inhibiting postoperative recurrence and brain metastasis of breast cancer