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In various embodiments, the first lipid-containing conjugation partner is a compound of the formula (IIA-1): the amino acid-comprising conjugation partner comprises a structure of the the conjugate is a compound of the formula (IC): wherein Ra, Rb, Rc, L1, L2, Z1, Z2, R1, R2, Rx, Ry, R3, R4, R5, R6, R7, R8, R9, A1, k, v, and n are as defined in the compound of formula (I) or any embodiment thereof

If one reduces Kupffer cell activation to protect the liver, could that compromise systemic pathogen clearance