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Abbreviations SLE: Systemic lupus erythematosus NW: Normal-weight EBW: Excess body weight DMCpGs: Differentially methylated CpG sites SAT: Subcutaneous adipose tissue CRP: C-reactive protein LDL-c: Low-density lipoprotein cholesterol HDL-c: High-density lipoprotein cholesterol IL-6: Interleukin-6 TNF-: Tumor necrosis factor alpha SLEDAI: Systemic lupus erythematosus disease activity index BMI: Body mass index CONSORT: Consolidated standards of reporting trials GEE: Generalized estimating equation IPAQ: International physical activity questionnaire TEI: Total energy intake SAM: S-adenosylmethionine THF: Tetrahydrofolate MTHFR: Methylenetetrahydrofolate reductase GO: Gene ontology KEGG: Kyoto encyclopedia of genes and genomes GSA: Gene-set analysis DMRs: Differentially methylated regions NES: Normalized enrichment scores GSEA: Gene set enrichment analysis ITT: Intention-to-treat SPSS: Statistical package for the social sciences References Tian J, Zhang D, Yao X, Huang Y, Lu Q