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While PKM2 predominantly exists as a catalytically active tetramer in normal tissues, it tends to adopt a low-activity dimeric form in CRC and various other tumor types

sedebokerense was constructed with the reference genome from the Joint Genome Institute ( Differentially expressed genes (DEGs) were identified by comparing the infected samples with the CK samples with the DESeq2 software package after a routine of robust quality checks [43]

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The December 2025 Phase 3 TRIUMPH-4 results were even more impressive, with the 12mg group losing an average of 28.7% of body weight over 68 weeks