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Acad Radiol

These pathways do not operate in isolation

The pineal gland's role in the body is not fully understood, and it is considered a less "sexy" area of research, but it is thought to be important for overall health and longevity, with some research suggesting that the decrease in pineal gland function with aging is more of a physiologic than an anatomic problem 2m6s

N,Nbis-(2-mercaptoethyl) isophthalamide (NBMI), a lipophilic thiol-based chelator with selective affinity for ferrous iron, has demonstrated superior brain chelation efficacy in a mouse model of brain iron overload, making it a promising candidate for IN formulations if its solubility limitations can be addressed (Cheng et al., 2022)