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72 A 2021 meta-analysis of 16 RCTs, involving 987 patients with SUDs, found a significant decrease in craving symptoms and a significant improvement in depressive and withdrawal symptoms with NAC compared with control, whilst lower smoking frequency failed to reach statistical significance

What is the physiology relevance of lipid peroxidation, and how can the promising preclinical studies be translated into effective clinical strategies

doi: 10.1111/j.1745-7262.2007.00238.x 64 HallSEAitkenRJNixonBSmithNDGibbZ

Hydrogen peroxide produced by endothelial and immune-system cells directly or indirectly by NADPH oxidases also acts as a signaling molecule in the vascular system modulating endothelial cell proliferation and survival, for instance [19]