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Life Sci 2025;362:123381

Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

On Thursday, the FDA kicked off a two-day meeting to assess the safety and efficacy of lab-made peptides, which some supporters claim can build muscle, treat injuries and look younger

The quantitative meta-analysis was restricted exclusively to randomized or controlled trials with placebo or untreated comparison groups