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ROS also attack unsaturated fatty acids in cell membranes and lipoproteins, triggering lipid peroxidation that compromises membrane integrity and fluidity [109]

Abbreviations AA: Arachidonic acid (20:4n-6) ALA: Alpha-linolenic acid (18:3n-3) BA 10: Brodmann area 10 CNS: Central nervous system cPLA2: A calcium-dependent AA-specific cytosolic PLA2 CSF: Cerebrospinal fluid DA: Dopamine (3,4-dihydroxyphenethylamine) DHA: Docosahexaenoic acid (22:6n-3) DPA: Docosapentaenoic acid (22:5n-3) EPA: Eicosapentaenoic acid (20:5n-3) FABP: Fatty acid binding protein FAD: Fatty acid desaturase GM: Grey matter GPCR: G-protein-coupled receptor GSH: Glutathione 5-HT: Serotonin (5-hydroxytryptamine) iPLA2: A calcium-independent DHA-specific PLA2 KYNA: Kynurenic acid LA: Linoleic acid (18:2n-6) NMDAR: N-methyl-D-aspartate receptor PANSS: Positive and negative symptom scale PFC: Prefrontal cortex PLA2: Phospholipase A2 PUFA: Polyunsaturated fatty acid PGE2: Prostaglandin E2 RBC: Red blood cells RCT: Randomized-controlled trial sPLA2: A calcium-dependent AA-specific secretory PLA2 SOD: Superoxide dismutase TAC: Total antioxidant capacity UHR: Ultra-high risk VTA: Ventral tegmental area WM: White matter References Kahn RS, Sommer IE, Murray RM, Meyer-Lindenberg A, Weinberger DR, Cannon TD, et al