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3 Arsenic metabolites In the majority of preclinical and clinical studies, ATO was administered intravenously at a daily dose of 10 mg or 0.15 mg/kg/day, typically until complete remission was achieved or for a maximum duration of 60 days ( After ingestion, ATO is absorbed into the bloodstream as arsenite (iAs III ) and subsequently transported to the liver, where it undergoes methylation ( V ) via phosphate transporter proteins and As III through aquaglyceroporins

While the differences in phenotypes may stem from the experimental and/or environmental conditions, IRE1 can engage multiple pathways independent of XBP1 activation

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