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Limitations in Clinical Assessment The subjective and heterogeneous nature of tinnitus continues to hinder the development of objective diagnostic and evaluative tools, complicating both the clinical trial design and regulatory approval processes

These shifts may suggest a potential support for ligand-binding interactions

This was seen before with vessel occlusion (Vukojevic et al., 2018

Mechanistically, impaired iron exporte.g., zinc-mediated inhibition of amyloid precursor protein (APP) ferroxidase activityprovides a route to local iron accumulation (Duce et al., 2010), while familial AD presenilin mutations confer selective vulnerability to ferroptosis in human neuronal models (Greenough et al., 2022)