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In conclusion, through comprehensive bioinformatics analysis and multiple machine learning methods, this study successfully identified and validated GPX3 and MYC as two key genes related to gut microbial metabolism and ferroptosis in RA progression

As an example, the enrichment of genes associated with regional emphysema severity among genes differentially expressed with the presence of emphysema in the dataset from Golpon et al .[6] is shown in Figure 4c,d

Histopathology in the cerebral cortex, hippocampus and colon was assessed using an orthoptic light microscope (Eclipse E100, Nikon, Tokyo, Japan) equipped with a DS-U3 imaging system (Nikon)