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346 Therefore, the controversial role of H 2 S necessitates further exploration to provide stronger evidence for the perspective that H 2 S donors or enhancers of H 2 S signaling may improve adipose tissue dysfunction in common metabolic disorders (Fig

Some scientific publications also consider DSIP as a co-regulator of other neurohormonal systems, including somatotropin, prolactin, and ACTH, especially in the context of adaptation to physical exertion, overtraining, and chronic stress

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This immune activation may involve close interplay between intracellular complement regulation and NLRP3 assembly in either immune cells or the RPE, although a recent study argues against NLRP3 inflammasome activation in the RPE 40