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CHAC1 supplies the matrix cysteine pool in the absence of extracellular cystine To determine if CHAC1 has a discernable influence on the pools of mitochondrial cysteine and GSH in the potential support of Fe-S cluster synthesis, we endeavored to monitor the availability of these metabolites in response to cystine starvation (Fig

The astrocytic hemichannels are activated via increased Ca 2+ levels and inflammatory factors, such as IL-1, epidermal growth factor (Morita et al., 2007), or TNF (Giaume et al., 2013)

This is used to label usually 23 samples, but up to 5 samples (5-plex) can be labeled and pooled in a single experiment if other formaldehyde/cyanoborohydride isotopomers are used (Wu et al., 2014)

1a), whose structure was predicted using AlphaFold2 28