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KRAS -mutant tumours exhibit intrinsic resistance or acquire adaptive resistance through diverse molecular and cellular mechanisms, as summarised below (figure 2)

32 The positive association between frequency of MTHFR -C677T and MTHFR -A1298C polymorphisms and latitude documented in the current study suggests that in areas closer to the equator, which are increasingly exposed to UVR, activity of the MTHFR enzyme reflects greater functional competency because of the absence of the MTHFR polymorphisms

Detailed chemical mixture characterisation were provided by some of the papers assessed here (Reference Amara, Ontario and Scuto21,Reference Perveen, Mushtaq and Yousaf38)

In adult patients, Czaja et al