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Evaluation of Selected Natural Compounds as Dual Inhibitors of Catechol-O-Methyltransferase and Monoamine Oxidase. Central Nervous System Agents in Medicinal Chemistry, vol

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In contrast to the clinically prescribed periocline, the injectable PCN-222-Pt ointment demonstrated a reduced bone degradation rate, healthier periodontal tissue, and an alleviation of inflammation response in treating biofilm-induced periodontitis

It also activates mast cells and Kupffer cells, increasing histamine and TNF- levels, thereby exacerbating hepatocellular damage through oxidative and inflammatory pathways [65]