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BMC Physiol

doi: 10.1016/j.ynstr.2020.100286 167 TovoteP.FadokJ

Glutathione functions as the primary intracellular reducing agent, maintained predominantly in its reduced (GSH) form by glutathione reductase using NADPH as a cofactor

Importantly, these clinical studies have been limited by small sample sizes and did not explore mechanisms underlying any potential opioid-mediated effects