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The gsa2 strain itself is known to show a stronger GSAAT deficiency phenotype than its gsa1 counterpart ( gsa2 background ( Supplementary Figure 3A )

Per Med

This is described by the hypothalamic-pituitary-adrenal axis and occurs when the immune system recognizes a foreign agent and produces chemical messengers known as cytokines

Both mouse primary cortical neurons (10 or 20 M for 3 or 6 h) and a triple-transgenic AD mouse model treated with SF (56.4 or 282 mol/kg/day for 6 days/week for 8 weeks) exhibited enhanced brain-derived neurotropic factor (BDNF) expression, crucial for neuronal survival and synaptic plasticity, suggesting a potential epigenetic mechanism for SFs neuroprotective effects (61)