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The combination is well-tolerated because cagrilintide targets amylin receptors while semaglutide activates GLP-1 receptors, meaning the mechanisms dont overlap and produce additive effects rather than redundant signalling

USA 107 , 1577415779 (2010)

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J Nutr Biochem 13:444461 Castell JV, Gomez-Llechon MJ, David M et al (1990) Acute-phase response of human hepatocytes: regulation of acutephase protein synthesis by interleukin-6