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If a biological product was previously licensed under a different regulatory pathway (e.g., as a biologics license application converted from an NDA during the transition of protein products to biologics regulation), the first licensure date may significantly predate the current BLA holders commercial launch

Recent developments in automated sampling of blood (159) and tissue interstitial fluid via microdialysis (160) have also uncovered the ultradian rhythms in plasma ACTH which correlate well with plasma and tissue steroid (cortisol and cortisone) concentrations, indicating that the ultradian rhythms in blood ACTH and cortisol/cortisone translate well to tissue exposure to these steroids

Waugh SM et al

Verapamil and drugs such as vincristine however, when bound in zone D, probably interact with MRP1 in different ways, as already suggested 8 and stimulate GSH uptake also in different ways