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These include concerns regarding the long-term safety of gene modifications, challenges in the mass production of gene drugs, difficulties in controlling gene expression in vivo, limitations in achieving stable and long-term expression of foreign genes in vivo, low efficiency of targeted gene transfer, alterations in the biological properties of target cells, and ethical considerations

Acta Pharmacologica Sinica 38 (6), 754763

Examination reveals a papulosquamous eruption characterised by often well-defined erythematous patches and thin plaques covered with bran-like, greasy scales