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23 In Enterobacteriaceae , a variety of -lactamases, including extended-spectrum -lactamases (ESBLs) and carbapenemases (KPC, NDM, VIM, OXA), are present and confer resistance against last-resort antibiotics like carbapenems

In addition, the interaction between tumor metabolism and the acidic microenvironment is bidirectional, as lower pH inhibits enzymes involved in glycolysis (such as phosphofructokinase-1) and may inhibit tumor cell proliferation and survival (112)

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FOXO4-DRI (Forkhead Box O4-D-Retro-Inverso) is a rationally designed synthetic peptide that functions as a selective senolytic agent, specifically targeting senescent cells for elimination while leaving healthy cells unharmed