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Cysteine and glutamate transfer throughout the cell membrane and GSH synthesis relies on the Xc-antioxidant system, comprised of the SLC7A11 and SLC3A2 bis-subunits (Chu et al., 2017)

Virchow first noted that inflammatory cells are present within tumors and that tumors arise at sites of chronic inflammation [60]

Collectively, these findings demonstrate that gut-derived inflammatory cascades mediated by TLRs/NLRs signaling pathways serve not only as key drivers of experimental pulmonary injury, but their persistent activation likely contributes to the pathological progression of advanced diabetic complications (e.g., diabetic lung disease)