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Targeting cell cycle and apoptosis pathways p53/mouse double minute 2 homolog (MDM2)/ARF and p16/cyclinD-CDK4/6/Rb signaling pathways regulate cell cycle and cell proliferation

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However, some conditions can boost the production of free radicals and create oxidative stressa condition in which the body's antioxidant defenses are unable to neutralize the overwhelming quantity of free radicals being produced