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Effect of sulforaphane on UC-induced activation of oxidative stress Induction of UC in rats leads to 71% and 66% reduction in the gene expression of Nrf2 and HO-1, respectively, associated with 61% and 59% reduction in protein levels of Nrf2 and HO-1, respectively, in the colon of rats as compared with the control rats

This can trigger mitochondrial dysfunction and the production of additional ROS.Mitochondrial Activity: Neurons are highly dependent on mitochondria for energy production, and mitochondrial respiration is a significant source of ROS

Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394

The H 2 O 2 was then added, and flasks were shaken vigorously under oxic conditions