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10.1016/j.arcmed.2021.12.001 64 HouL.ZhaoY.SongG.-q.MaY.-h.JinX.-h.JinS.-l.et al (2019)

242244 Globally, regulatory bodies have implemented guidelines for herbal product registration and quality assurance, although frameworks differ significantly across regions

However, interest in this subject has grown dramatically, culminating in the inclusion of reprogrammed energy metabolism in the 2011 updated hallmarks of cancer (Hanahan and Weinberg, 2011)

[63] found that the enzyme dihydroorotate dehydrogenase (DHODH) and mitochondrial GPX4 constitute two additional defense enzymes that can detoxify lipid peroxides in the mitochondria